Organization of Living Matter - ESO 3 Biology and Geology

What to Learn

Levels of organisation in living beings: overview.
Bioelements.
Biomolecules: organic and inorganic; main types; their role in the human being.
Cells: unicellular and multicellular beings; eukaryotic and prokaryotic cells and organisms; components (and their functions) of prokaryotic, plant and animal cells.
Overview of the cell activity: nutrition, interaction and reproduction.
Supracellular levels of organisation: thalluses, tissues, organs, systems of organs, apparatuses.

Basic Information

Levels of Organisation in Living Beings

Living beings are formed by clusters of matter increasingly bigger and complex. These clusters of matter are classified in levels: every new level is more complex than the previous one. The simplest organisms (bacteria, protozoa, unicellular algae and yeasts) only reach the cellular level, but the more sofisticated ones also have tissues, organs and systems of organs.

	Examples
Bioelements	C, H, O, N, P, S
Biomolecules	Carbohydrates, proteins, lipids, vitamins, nucleic acids, water, mineral salts
Cells	Sperm cell, palisade cell, muscular cell, neurone…
Tissues	Muscle tissue, nerve tissue, blood…
Organs	Brachial biceps, heart, brain, leaf, root…
Systems of organs	Digestive system, nervous system, circulatory system, skeleton…
Apparatus	Motor apparatus
Multicellular organism	A person, a cat, a fungus, a black poplar…

Bioelements and Biomolecules

The bioelements are most abundant chemical elements in a livig being, which are not much the same ones that you can find in a rock or in the air. The top six are C, H, O, N, P, S, and they're called primary bioelements.

The molecules that can be found in all living beings, from the simplest bacterium to the most complex animal, are called biomolecules, the molecules of Life. There are two types:

· Organic: Carbohydrates, proteins, lipids, vitamins and nucleic acids. They all have an inner skeleton built mainly with carbon atoms, which allows for a really large size. The organic biomolecules can only be produced by living beings, if we discard artificial synthesis. This is, they can not be produced by geological or atmospheric processes, for instance.
· Inorganic: Water and mineral salts. They don't have an inner skeleton of carbon atoms and can be produced in non-biological processes.

Cells

All living beings are made up of complex structures called cells. Cells are made up of billions of biomolecules working together. Viruses are not regarded as living beings because they are not made up of cells.

Living beings can be (a) unicellular: made up of just one cell (bacteria, protozoa, many algae, yeasts); and (b) multicellular: made up of more than one cell: (some algae, most fungi, plants and animals).

All cells are able to perform the three vital functions: (a) they reproduce, quite usually by mitosis, a process that yields two daughter cells with almost identical genetic material; (b) they interact with their environment, giving responses to specific stimuli, as when a white blood cell is able to detect and destroy a bacterium; and (c) they feed, meaning that they are able to exchange matter and energy with their environment, as when a human cell takes oxygen from the blood and releases carbon dioxide.

All the cells have (a) a cell membrane, which is the cellular envelope, (b) a cytoplasm with organelles, which are specialized cell compartments where specific functions are fulfilled, and (c) genetic material, that carries the instructions that allow both the cellular work and its self-construction.

There are two main kinds of cells: (a) the cells of the bacteria and archaea have no real nucleus: they are said to be prokaryotic; (b) the cells of all the other living beings (algae, protozoa, fungi, plants and animals) have their genetic material separated from the cytoplasm by a nuclear membrane: they are said to be eukaryotic.

The cells of the plants can be easily distinguished from those of the animals because (a) they have a semi-rigid cell wall, made of cellulose, surrounding the cell membrane, that usually gives the cell a polyhedral shape; (b) they have one kind of organelles, called chloroplasts, where sunlight energy is used to start building their own organic substances through a chemical process called photosynthesis; (c) they use to have one or a few big vacuoles that contain sap (instead of lots of smaller ones without sap) which normally push the nucleus out to the periphery of the cell; and (d) although they have equivalent structures, they lack centrosomes, the organelles that control the arrangement of the chromosomes during mitosis in an animal cell.

Common Structures in Eukaryotic Cells

	Description	Function	Where
Cell wall	Outermost layer of a plant cell composed of cellulose and other complex carbohydrates.	Helps to support and protect the cell.	P
Flagella (flagellum)	Long and scarce threadlike structures that extend from the surface of the cell.	Used for movement of the cell or to move fluids over the cell's surface for absorption.	A
Cilia (cilium)	Short and abundant threadlike structures that extend from the surface of the cell.	Used for movement of the cell or to move fluids over the cell's surface for absorption.	A
Cell membrane	Outer layer composed of lipids and proteins.	Controls the permeability of the cell to water and dissolved substances.	A, P
Cytoplasm	Viscous fluid mixture that occupies most of the cell's interior. Wraps the nucleus and contains biomolecules, organelles and a protein fiber network (the cytoskeleton).	Medium in which organelles and other internal structures exist in. The fiber network makes the cytoskeleton, which supports the shape of the cell and anchor organelles to fixed positions.	A, P
Mitochondria (mitochondrion)	Elongated organelles enclosed in a double membrane, the inner one with folds called cristae.	Sites of cellular respiration, which converts sugars and fats into energy through oxidation.	A, P
Chloroplasts	Elongated organelles enclosed in a double membrane and with vesicles containing chlorophyll.	Sites of photosynthesis.	P
Ribosomes	Tiny organelles composed of proteins and RNA, not enclosed in a membrane. Some are free in the cytoplasm, some are attached to endoplasmic reticulum. They are the only organelles present in all cells, including prokaryotics.	Sites of protein synthesis.	A, P
Endoplasmic reticulum	Extensive system of internal membranes. May be smooth or rough: the latter has ribosomes attached to its membrane.	Site of synthesis, modification and transport of various organic biomolecules.	A, P
Golgi apparatus	Flattened stacks of membranes.	Used in the collection, packaging, and distribution of synthesized molecules.	A, P
Secretory vesicles	Membrane enclosed sacks created at the Golgi apparatus.	These structures contain cell secretions, like hormones and neurotransmitters. The secretory vesicles are transported to the cell surface where they release those substances outside the cell (exocytosis).	A, P
Vacuoles	Elongated organelles enclosed in a membrane. Few and large in plant cells.	Used to store sap (water and sugars) or waste products.	A, P
Lysosomes	Spherical organelles enclosed in a membrane.	Contain digestive enzymes for breaking down old cellular components or ingested food (smaller cells, big macromolecules).	A, P
Centrosome	A pair of hollow tubes (the centrioles) surrounded by protein fibers in a star-like arrangement. Plant cells have an equivalent structure.	Move and organise chromosomes during mitosis and meiosis.	A
Nucleus	Double membrane structure that encases chromatine.	Controls the cellular activity.	A, P
Chromatine	Long strands of DNA and protein. During cell division it is packaged into chromosomes.	The DNA stores hereditary information in small units of information called genes, and expresses it.	A, P
Nucleolus	Highly condensed chromatine loops.	Area were ribosomes are manufactured.	A, P

Tissues

In multicellular beings there may be different types of cells, each type being specialized in an specific function, and having the specific shape that allows them to fulfill that function the best. Each of those types is called a cellular tissue; examples are the vascular tissue (plants) or the blood tissue (animals). One tissue may have several subtypes of cells (e.g. white blood cells and red blood cells). The human body contains over 200 different types of cells.

The four main types of human tissues are the following:

Epithelial tissue	Composed of layers of cells that line organ surfaces such as the surface of the skin or the inner lining of the digestive tract. Serves for protection of organs (as in the skin), secretion of substances (when it forms glands - in the skin, in the digestive tract, etc.), and absorption of substances (as in the intestine).
Muscle tissue	Composed of very long cells (up to several cm) called muscle fibres. They have more than one nucleus, are able to expand and contract (thanks to a dense protein network that takes up most of the cellular space), and so, are specialized in movements. There are three kinds: cardiac muscle (found in the heart), skeletal muscle (attached to bones and under voluntary control) and smooth muscle (not in the heart or attached to bones and under involuntary control, as in the wall of the stomach).
Nerve tissue	Composed of cells with many projections that are specialized in contacting other cells and transmitting messages via electrical signals.
Connective tissues	Usually specialized in holding together different organs or tissues. It is composed of cells usually very separated by an abundant extracellular matrix. The main types are the bone tissue (in bones, with matrix rich in apatite, a mineral rich in P and Ca), the cartilage tissue (in cartilages), the adipose tissue (as in the fatty layer under the skin - the hypodermis), the fibrous connective tissue (in ligaments and tendons), the loose connective tissue (as in the skin's dermis) and the blood.

Organs, Systems and Apparatuses

There are some tasks in a multicellular being that must be achieved by cells of different kinds working together (such as pumping blood throughout the human body). In this case, cells of different tissues gather and make up an organ (epithelial, connective, muscle and adipose cells make up the heart).

Several organs working together in a common general task make up an organ system, e.g., the heart and the blood vessels make up the circulatory system. And when two organ systems work cosely together in a common function are said to constitute an apparatus: the muscular system and the skeleton form the motor apparatus, because both contribute to the function of locomotion in an animal.

Put simple, the human organ systems contribute to the three vital functions as follows:

· Nutrition is fulfilled through:

· The Digestive System, which (a) takes in the food, (b) breaks it down into nutrients and other substances, (c) absorbs the nutrients into the blood, and (d) gets rid of the non assimilable substances in the form of faeces.
· The Circulatory System (a) transports those absorbed nutrients to all the cells of the body and (b) transports waste substances to the kidneys, the sweat-glands and the lungs.
· The Excretory System expells of the waste substances arriving to the kidneys, by producing and releasing urine.
· The Respiratory System (a) takes in oxygen (a nutrient) which is absorbed into the blood and (b) gets rid of the carbon dioxide (a waste substance).

· Reproduction is carried out through the male and female reproductive systems which (a) produce the specialized reproductive cells (sperm and egg cells), (b) allow those reproductive cells to join in pairs, and (c) grow the embryo coming out of a fertilised egg-cell.
· Interaction is fulfilled through:

· The Sensory Organs, which continuously detect bits of information coming from the inside of the body or from the environment.
· The Nervous System, which collects that sensitive information, interprets it, and generates response orders.
· The Endocrine System, which cooperates in conveying those response orders by means of substances, called hormones, that are released by glands and travel through the blood.
· The Skeleton and the Muscle System, which carry out most of those response orders produced in the nervous system.

External Links

Bioelements and Biomolecules

The chemistry of life: the human body.You are what you eat. But do you remember munching some molybdenum or snacking on selenium? Some 60 chemical elements are found in the body, but what all of them are doing there is still unknown.

Basics of Biochemistry.The biomolecules and their roles in an easy-to-understand language.

Cells

Cells and Life processes.To understand the structure of plant and animal cells and their life processes. You can print the lesson text and read a glossary. Interactive lesson at Skoool.co.uk. (N.B.: In case your browser freezes, use Firefox and click on "Block Script" when asked).

Cell games.Excellent and easy to follow visual activity to learn the basics on animal, plant and bacterial cells.

Plant cells and animal cells.Great interactive animation showing the parts and organelles of both plant and animal cells.

Typical animal cell.Interactive activity to identify the parts of an animal cell and read about the function of its organelles.

Inside a cell.Take an interactive look inside an animal and a plant cell.

Cell size and scale.Awesome zoomable visualization to help you get an idea of the actual sizes of cells and their components.

Cells, tissues, organs and organ systems.Great presentation on cells, their parts, their types, their sizes and how they specialise in animals and plants forming tissues and organs.

Cell structure.To learn everything you need about the parts and the organelles of a cell in an easy-to-understand language.

Cellular organization.Lots of info and images on the cells and their organelles.

List of distinct cell types in the adult human body.Article at Wikipedia containing a list of links to the corresponding articles of a great number of types of human cells.

Regrowth mystery reborn.Debunking the idea that our bodies are renewed every seven years: learn what is the real life span of several types of human cells.

Tissues

Cells, tissues and membranes.Particularly interesting is that it includes a good overall view on the main human tissues, with text and images.

Animal cells and tissues.Lots of info and images on the animal tissues.

Organs, Systems and Apparatuses

Google body.On Zygote Body (old Google Body) you can view the underlying anatomical layers one by one using a slider, switch on labels to identify each body part, use the search box as a search engine for any body part (muscles, organs, bones etc), and what's more, you can also share the exact scene you are viewing by copying and pasting the URL. As of writing this, the website will only work in Firefox and Chrome browsers.

DirectAnatomy.DirectAnatomy.com comes with an interactive interface with four angles of view allowing you to browse through more than 1,200 annotated anatomy images. A clickable menu on the left displays the specific body part on the right. The human body tour also gives you an insight into the physiological and pathological makeup of our bodies.

The virtual body.The Virtual Body takes you on four tours: The Human Brain, Skeleton, Human Heart, and Digestive Tract. Then there are some cool standalone tours within each.

Human body & mind.The BBC's webpage is a resource rich place to discover and play interactive games while learning all about the human body. The games include Senses challenge, Organs Game, Skeleton Game, Muscle Game and Nervous System Game. The games are superbly designed and mostly involve dropping a body part onto a human figure.

Artificial anatomy.This one is not a fully fledged anatomical course, but a cool and short 10 question quiz on different body parts. It is a Smithsonian National Museum of Natural History resource. With a mouse rollover you have to match the thumbnail with its location on the skeletal structure named 'Jerome'. You can also turn Jerome around for another view.

Online examination of human anatomy and physiology.Visually learn about the human body using interactive flash animations.

The ultimate human body quiz.Not that much, but a set of ten not-so-easy questions to test your knowledge on the human body.

Zoom into hair.View the inner structure of a hair, progressively magnified.

Zoom into a tooth.View the inner structure of a tooth, progressively magnified.

Anatomy of the human body.The Bartleby.com edition of Gray's Anatomy of the Human Body features 1,247 vibrant engravings—many in color—from the classic 1918 publication, as well as a subject index with 13,000 entries.

Movies, Animations and Audios

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Biomolecules

Carbohydrates

Great video that makes use of the Periodic Table to explain how a glucose molecule, the primary component of many bigger carbohydrates, is chemically constructed.

Produced by Cassiopeia Project

Lipids

See how a triglicerid, the most typical lipid molecule, is built from three fatty acids and one molecule of glycerine.

Produced by Cassiopeia Project

Proteins

Learn how a protein molecule is built up until it is fully functional.

Produced by Cassiopeia Project

DNA Structure

Learn how a molecule of DNA is structured.

DNA

Learn the structure, organisation and function of DNA.

Produced by Cassiopeia Project

DNA wrapping and replication

The first part shows the DNA coiling four consecutive times to make up the chromosomes. The second shows the process of DNA duplication before cell division.